Materials and methods: Thirty male Sprague–Dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with GSP. After isolation of non- degenerative and degenerative nucleus pulposus cells (NPCs), the targeting relationship between miR-125a and BAK1 was verified by dual luciferase reporter gene assay. The rats were divided in 5 groups: control (normotensive) group, Desoxy cortico sterone (DOCA)-salt hypertensive group, and three DOCA-salt hypertensive groups. Experimental rats were fed with high fructose diet for 6 weeks and then were treated with Z. multiflora extract or a pioglitazone solution for 2 weeks. After Quer treatment, viability, migration, and cell apoptosis of PC-12 cells were analyzed by CCK-8 assay, transwell assay and flowcytometry analysis, respectively. We also characterized these cells immunohistologically using various pluripotent stem cell markers. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. Bacopa monnieri (BM), a traditional ayurvedic medicine, is a well-known memory enhancer. This effect could be attributed to hypoglycemic, hypolipidemic and antioxidant activity of A. marmelos. However, the effects of other fractions were significantly lower than theophylline in both groups (p< 0.01 to p< 0.001). Collectively, our data suggest that NADPH oxidases, particularly NOX1 and NOX2 are relevant sources of ROS in the aorta of aged SHR thereby cause endothelial dysfunction, and VAS2870 is effective as apocynin in reversing these consequences.Aorta, Endothelial dysfunction, Oxidative stress, Spontaneously hypertensive rats. However, NOX4 protein expression was not significantly changed. After peer-review by expert national and international reviewers, 15 % of submitted papers were accepted for publication. Selection of the appropriate target site is essential in the success of an AO therapy. Objective(s) The control animals received an equivalent volume of normal saline. Results: 16, No. In each group of animals, spatial learning and memory parameters were analyzed. The extract (25–250 mg/kg) administered 1 hr before carrageenan-induced paw swelling produced a dose dependent inhibition of the oedema. GSTM1 and GSTT1 null deletions genotypes were determined in 22 (53.7%) and 7 (17.1%) patients with PCAG and 34 (34%) and 15 (15%) in healthy subjects. The risk factors of clustering among tuberculosis patients were age < 45 years, new cases, degree of sputum smear ≥ 2+, and close contact. Data also indicated that enzymatic region of hyaluronidase protein from Streptococcus pyogenes was recognized in all 5 patient's sera. Male Wistar rats were randomly divided into normal-control, diabetic-control, and A. marmelos-treated diabetic groups (100, 250 and 500 mg/kg, p.o.). Conclusion 22, No. This study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (I/R) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. The results showed that BM at the dose of 120 mg/kg significantly (P<0.05) restored the levels of oxidants and the activities of antioxidant enzymes in frontal cortex and hippocampus of neonates against PBDE-209-induced toxicity. Conclusion: The most prevalent blood group was type AB with positive Rh-phenotype (82.4%). This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM33 gene have been assessed in patients with allergic asthma and normal controls (95 patients and 86 normal). The Standard Abbreviation (ISO4) of Iranian Journal of Basic Medical Sciences is “Iran J Basic Med Sci”. Results: The relaxant effects of three cumulative concentrations of each fraction (0.1, 0.2 and 0.4 g%) in comparison with saline and three cumulative concentrations of theophylline (0.1, 0.2, and 0.4 mM) were examined on precontracted tracheal chains of guinea pig by 60 mM KCl (group 1, n= 5) and 10 µM methacholine (group 2, n= 8). Furthermore, the impaired acetylcholine-induced relaxation of SHR aorta was significantly improved in the presence of either apocynin or VAS2870. Ionic channels on GBCs were studied with voltage clamping. Objective(s): Basal cell markers can help to distinguish prostate adenocarcinoma from cancer mimickers. D. aucheri could be useful in treatment of diabetes. Cell proliferation-associated proteins and cell apoptosis-associated proteins were analyzed by Western blot. After SDS gel electrophoresis and silver nitrate staining, Western blotting was done for porin, adenine nucleotide translocase and cyclophilin-D proteins.Results Porin was purified from mitochondrial mixture in ischemic brain and control groups. The journal publishes basic and translational/clinical research submissions in all biomedical specialties, including Genetics and Molecular biology, Immunology, Microbiology, Pathology, Biochemistry, Pharmacology, Anatomy, Biomaterials, new and emerging research and diagnostic methods, new and emerging medical entities, and others. p63 and 34βE12 were negative in all prostate adenocarcinoma specimens, but all benign prostate hyperplasia and high grade intraepithelial neoplasia cases expressed them. Extraction of DNA from Mycobacterium strains and DNA fingerprinting with IS-6110, PGRS and DR probe were performed by standard protocols. Glutathione S-transferases (GSTs) are members of multigenic family, which have important role in cells as an antioxidant. Diabetes was induced in rats by intraperitoneal injection of streptozotocin (50 mg/kg). Materials and Methods ISSN; 20083874, 20083866. Prevention of ovarian I/R injury-related infertility in rats with induced diabetes is not through antioxidant activity. GSTM1and GSTT1 polymorphisms were determined by multiplex polymerase chain reaction. Meanwhile, si-VEGF could reverse the effect of miR-103 inhibitor on angiogenesis in rats subjected to MCAO. Impairment of nerve cells of brain induced by hypoxia results in energy-deprivation and dysfunction, which accompanies with neurons apoptosis. This is a short guide how to format citations and the bibliography in a manuscript for Iranian Journal of Basic Medical Sciences (IJBMS). We have investigated the effect of Q223R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. Objective(s): Here we investigated the expressional regulation of NADPH oxidase isoforms (NOX1, NOX2 and NOX4) in aorta of aged spontaneously hypertensive rats (SHR) in comparison to age matched Wistar Kyoto rats (WKY). Materials and Methods: Iran J Basic Med Sci, Vol. Objective(s) Results: The Journal Impact 2019-2020 of Iranian Journal of Basic Medical Sciences is 1.960, which is just updated in 2020. We found that the thoracic epidural blockade significantly decreased chronic hypoxia-induced pulmonary hypertension and vascular remodeling in rats. Iranian Journal of Basic Medical Sciences Inactivation of mitogen-activated protein kinase signaling pathway reduces caspase-14 expression in impaired keratinocytes No effect was observed with the dextran-induced oedema model. Real-time PCR and western boltting were employed to examine the expression of cAMP responding-element binding protein (CREB). The burst was significantly lower with composite microparticles and may be explained by lower diffusion of the drug from double polymeric wall formed by the nanoparticles matrix followed by another diffusion step through the microparticle polymeric wall. Mild hypothermia (33±0.5°C) for 6 hr was initiated at the start of reperfusion. Materials and Methods: We also found that AMPK and Wnt/β-catenin signaling pathways were activated by Quer in hypoxia-induced injury, but were inactivated in hypoxia-induced cells by overexpression of miR-122. The dry roots of CG were smashed and percolated with 95% ethanol, and the residual was prepared into petroleum ether extract (CG-V), ethyl acetate extract (CG-VI) and n-butyl alcohol extract (CG-VII). Thoracic epidural blockade reduced mPAP and serum level of TNF-α and increased cGMP. Results: Although carefully collected, accuracy cannot be guaranteed. Organ indices and serum levels of glutamic-oxaloacetic and glutamic-pyruvic transaminases of intragastrically administered rats were obtained. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was utilized to assess the expression of miRNAs and mRNAs, in 40 RR-MS patients and 11 healthy individuals. An up-regulation of miR-9-5p and down-regulation of miR-106a-5p in relapsing phase of MS patients were observed compared to healthy controls. The drug loaded composite microspheres (F9) showed minimum burst effect, acceptable release and mean particle size 17.696 µm. Materials and Methods: In H. pylori infected individuals the seroprevalence of anti-CagA antibody was 46.9%. ResultsClear impairment of spatial learning and memory was observed in diabetic group versus normal-control group. No antipathogenic and antioxidant activity were found for oxypeucedanin in this study. Polymorphisms of ADAM33 gene might be associated with severe asthma and sensitivity to aeroallergens in northeast of Iran, but further studies are needed to determine the polymorphisms in this area and other regions of our country. It has been notified that ion channels' activities in cardiomyocytes are sensitive to the ATP level. Objective(s): Moderate dose of D. aucheri (200 mg/kg) was more effective than the others. When categorizing the asthmatic patients in severe, moderate and mild groups, associations in the subcategories of asthmatic patients were found. Recent evidence indicates that Interleukin 17 (IL-17)-producing T helper cells (Th17 cells) population are increased and regulatory T cells (Treg cells) are decreased in MS. It is used both as a prophylactic drug and to prevent acute exacerbations of asthma. Ropivacaine-treated rats exhibited significantly lower mean pulmonary artery pressure (mPAP), ratio of right ventricular weight to left ventricular plus septal weight (RV/(LV+S)) and wall thickness of pulmonary artery compared with those of control rats. RORC and FOXP3 were up-regulated in relapsing and remitting phases of MS, respectively. Mild hypothermia decreases infarct volume after cerebral ischemia-reperfusion, reduces Fas and MMP-3 expression, but increases FasL in cerebral ischemia-reperfusion rats. Conclusion: Objective(s): Objectives: The Iranian Journal of Medical Sciences (IJMS) is an international peer-reviewed bimonthly biomedical publication, the aim of which is to provide a scientific medium of communication for researchers throughout the globe. Antibiotic resistance in Acinetobacter baumannii and outbreaks caused by this organism have been reported from several areas of the world. Serum nitric oxide (NO) was assayed by colorimetric. Rats were injected with saline or ropivacaine. This study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. The correct choices and reference/working memory errors of young mice were evaluated by Morris water and radial arm maze. The administration of MESA significantly (P< 0.05) decreased the CECs number compared to hypertensive groups. Insulin and adiponectin levels were assayed by enzyme-linked immunosorbent assay (ELISA) method. Journal Impact 2018 di Iranian Journal of Basic Medical Sciences è 1.960 (Ultimi dati nel 2019). Additionally, there were significant association between Q223R genotypes and breast cancer risk; homozygotes for RR genotype (OR= 6.840; 95% confidence interval [CI] = 2.434-19.218), heterozygotes for QR (OR=3.024; 95% CI = 1.620-5.644, P = 0.001), and QR+RR genotype (OR= 3.522; 95% CI = 1.934-6.414, P < 0.001), respectively. Materials and Methods The role of alkaloids, flavonoids and triterpenoids will evaluate in future studies. 【Iranian Journal of Basic Medical Sciences】CiteScore Trend: Comments from Authors * All review process metrics, such as acceptance rate and review speed, are limited to our user-submitted manuscripts. For evaluating of analgesic and anti-inflammatory activity, we used the carrageenan- and dextran-induced paw oedema, acetic acid-induced writhing, tail flick and formalin pain tests.ResultsThe extract of T. chamaedrys (50–200 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant (P< 0.01) inhibition of the second phase response in the formalin pain model, while only the high dose (200 mg/kg) of the extract showed an analgesic effect in the first phase. All patients were graded according to the Pfirrmann criteria. Objective(s)Diabetes mellitus is associated with disturbances of learning and memory and cognitive functioning. Considering the beneficial antidiabetic potential of A. marmelos, this study was conducted to evaluate the effect of chronic oral administration of A. marmelos as cognitive enhancer, on learning and spatial memory in diabetic rats using Morris water maze test. Treated starch exhibited suitable flow properties and tablets made by the treated powder had relatively high hardness. Aegle marmelos Corr. Results The sample of the research was an Iranian family with LQTS for mutations by PCR-SSCP and DNA sequencing. Inhibition of miR-103 could promote ischemic stroke angiogenesis and reduce infarction volume via enhancing VEGF, which provides a new target for the clinical treatment of ischemic stroke. Ultimately, blood of animals has taken and glucose, insulin, lipid profiles, SGPT, alkaline phosphatase, SGOT, leptin levels were assayed. Thus, FOXP3 and RAR-related orphan receptor γt (RORγt) was assessed in CD4⁺T-cells by flow cytometry. Myocardial tissues were obtained, embedded in conventional paraffin, sectioned, and stained with hematoxylin. This study demonstrated high genetic diversity of OXA genes among isolates of A. baumannii in Qom, Iran. The mean of TUNEL positive cell numbers per unit area (NA) in different regions of hippocampus were compared in all animal groups. Results Hypoxia-induced increase in levels of serum cGMP and TNF-α was reversed by thoracic epidural blockade. The frequency of 223 RR genotype was significantly elevated in breast cancer cases as compared to controls (χ(2)= 20.072, P<0.001). Levels of malondialdehyde, protein carbonyl and activities of superoxide dismutase and glutathione peroxidase were measured at both ages. Quantitative computer-assisted morphometric study was done on hippocampus. Immunohistochemistry was performed to determine expression Fas, FasL, and MMP-3. Conclusion: Voltage gated Na+ channels were completely absent, which proves the unexcitable nature of GBCs. Materials and Methods In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. Cerebrum of six offsprings in each group was removed and stained with cresyl violet and a monoclonal antibody NeuN for immunohistochemical detection of surviving pyramidal neurons. As such they may not reflect the journals' exact competitiveness or speed. 180: 2013 “Silymarin”, a promising pharmacological agent for treatment of diseases. We found the reduced miR-103 in rats after MCAO. It also examined the effects of the drugs aimed at preventing infertility that may result from I/R injury. Helicobacter pylori infection occurs worldwide, but the prevalence of this infection varies greatly among different countries and population groups. Materials and Methods Higher temperature of the system during agglomeration process favors the formation of more regular agglomerates with mechanically stronger and denser structure; this can be explained by the promotion effect of temperature on the agglomeration process. As mitochondrial oxidative stress is probably entailed in ATP production, a candidate modifier factor for the long QT syndrome (LQTS) could be mitochondrial DNA (mtDNA). Also the extract reversed back the serum levels of SGPT, alkaline phosphatase and SGOT to near normal in treated diabetic rats. The antigenic property of the produced protein is well retained. Similar significance differences were also found in allele frequencies for Q and R between two groups (χ(2)= 19.027, P< 0.001). CC BY-NC 4.0 by Journal of Basic Research in Medical Sciences (JBRMS) is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Diabetes was induced by a single dose i.p. Additionally, we found that miR-103 could directly target VEGF and thereby lead to the down-expression of VEGF. In addition, the effect of ethyl acetate fraction in group 1 was significantly higher than those of theophylline (p< 0.05 to p< 0.001). Flow cytometry was determined the NPCs apoptosis, and Western blot to measure the expressions of BAK1, Caspase-3, Bax and Bcl-2. Materials and methods: Iranian journal of basic medical sciences 14 (4), 308, 2011. Iranian Journal of Basic Medical Sciences . In a cross-sectional and prospective study, 95 strains of M. tuberculosis isolates were selected for DNA fingerprinting. IJBMS, in 2014, continued the rapid forward trend of the recent years, notably 2011 through 2013. New Journal website launched Journal of Basic Research in Medical Sciences has received approval from the Commission for Accreditation and Improvement of Iranian Medical Journals . Objective(s): Conclusion: D. aucheri has highly significant blood glucose lowering effect. Materials and Methods: Thirty female mice were randomly allocated into cases and controls. Iranian Journal of Basic Medical Sciences Gabapentin enhances anti-nociceptive effects of morphine on heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain Gholam Ali Hamidi 1, Majid Jafari-Sabet 2, Alireza Abed 4, 5, Azam Mesdaghinia 1, 4, … Degree of pulmonary vascular remodeling was determined by Hematoxylin and Eosin (HE) staining. This enzyme is directly associated with the spread of the organism during infection. Materials and Methods: However, the specific isoform of NADPH oxidases that may predominantly contribute to these events remains to be clarified. Iranian Journal of Basic Medical Sciences comes of age on the 20 th anniversary of publication Iran J Basic Med Sci . Despite extensive research in understanding the mechanism of Th17 and Treg differentiation, the role of microRNAs in MS is not completely understood. Enzymes digestion analysis, sequencing results showed that the target gene (1296 base pair) was inserted correctly into the recombinant vector. Considering the beneficial antidiabetic and antioxidant potential of A. marmelos, this study was conducted to evaluate the effect of oral administration of A. marmelos on learning and spatial memory in diabetic rats using Morris water maze test.Materials and Methods There was no association between asthmatic patients and polymorphisms of alleles, genotypes and haplotypes of the ADAM33 gene. Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. Improving function of nerve cells is important for treating cerebral anoxia. P63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers, Association of ADAM33 gene polymorphisms with allergic asthma, Seroprevalence of anti-Helicobacter pylori and anti-cytotoxin-associated gene A antibodies among healthy individuals in center of Iran, Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats, The mitochondrial DNA mutations associated with cardiac arrhythmia investigated in an LQTS family, Effect of thoracic epidural blockade on hypoxia-induced pulmonary arterial hypertension in rats, Effect of Scurrula atropurpurea on nitric oxide, endothelial damage, and endothelial progenitor cells of DOCA-salt hypertensive rats, Effect of leptin receptor Q223R polymorphism on breast cancer risk, Expressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy, Protection of rats from thioacetamide-induced hepatic fibrosis by the extracts of a traditional Uighur medicine Cichorium glandulosum, Cloning and expression of the enzymatic region of Streptococcal hyaluronidase, Modification of flow and compressibility of corn starch using quasi-emulsion solvent diffusion method, Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle, Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice, Evaluation of Porin Interaction with Adenine Nucleotide Translocase and Cyclophilin-D Proteins after Brain Ischemia and Reperfusion, The effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus, The Effect of Chronic Administration of Aegle Marmelos Seed Extract on Learning and Memory in Diabetic Rats, Role of NADPH Oxidase in the Endothelial Dysfunction and Oxidative Stress in Aorta of Aged Spontaneous Hypertensive Rats, Design of Agglomerated Crystals of Ibuprofen During Crystallization: Influence of Surfactant, Effect of temperature on wet agglomeration of crystals, Analgesic and Anti-inflammatory Activity of Teucrium chamaedrys Leaves Aqueous Extract in Male Rats, Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats, Immunohistological and electrophysiological characterization of Globose basal stem cells, Bilateral ovarian ischemia/reperfusion injury and treatment options in rats with an induced model of diabetes, Bioscreening of Oxypeucedanin, a Known Furanocoumarin, Prenatal morphine exposure reduces pyramidal neurons in CA1, CA2 and CA3 subfields of mice hippocampus, Preparation and Evaluation of Poly (-caprolactone) Nanoparticles-in-Microparticles by W/O/W Emulsion Method, Mild hypothermia reduces expression of Fas/FasL and MMP-3 after cerebral ischemia-reperfusion in rats, Comparison of the genetic convergence between mycobacterium strains by three RFLP-based methods in central province of Iran, The Differences in the Relaxant Effects of Different Fractions of Rosa damascena on Guinea Pig Tracheal Smooth Muscle, Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats, Glutathione s-transferase M1 and T1 genetic polymorphisms in Iranian patients with glaucoma, MiR-103 regulates the angiogenesis of ischemic stroke rats by targeting vascular endothelial growth factor (VEGF), MiR-9-5p and miR-106a-5p dysregulated in CD4+ T-cells of multiple sclerosis patients and targeted essential factors of T helper17/regulatory T-cells differentiation, Restoration of correct splicing in IVSI-110 mutation of β-globin gene with antisense oligonucleotides: Implications and applications in functional assay development, Quercetin protects PC-12 cells against hypoxia injury by downregulation of miR-122, Downregulation of microRNA-125a is involved in intervertebral disc degeneration by targeting pro-apoptotic Bcl-2 antagonist killer 1, First report of OXA-143-lactamase producing Acinetobacter baumannii in Qom, Iran, instructions how to enable JavaScript in your web browser.

iranian journal of basic medical sciences

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