The folk healers of Russia used Red clover to treat asthma. And they are going to start consuming it in very large amounts! Here are a few of the most common uses. It is not recommended for women with estrogen-receptor-positive breast cancer. In addition, it protected dopaminergic neurons against lipopolysaccharide-induced damage by inhibiting microglial activation and proinflammatory factors (3). Data from clinical trials suggest that supplementation with red clover isoflavones helps relieve menopausal symptoms. Otherwise there is no stand Your generosity makes this possible. 2002;42:187-93. Red Clover Uses. The formula was developed after his grandfather observed what sick horses grazed on to restore their health. Cuts down on the risk of breast cancer. Red clover: Red clover has been hailed as "the" herb for cancer by many herbalists. Nourishing food herbs like Red Clover have been used for thousands of years with no indication the plant contributed to estrogen dominant conditions or estrogen-sensitive cancers. Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial. Do not take red clover if on a blood thinner, or when using melilot an herb that enhances bleeding. Like peas and beans, red clover belongs to the family of plants called legumes. Clinical relevance has yet to be determined.Cytochrome P450 enzymes: Preclinical studies suggest red clover can inhibit CYP 1A2, 2C8, 2C9, 2C19, 2D6, and 3A4, and may interact with substances metabolized by these enzymes (17) (28). Altern Ther Health Med. Those with hormone-sensitive conditions, such as breast cancer, ovarian cancer, or endometriosis,... Drug interactions. Data on red clover’s potential for reducing the symptoms of menopause and for decreasing the risk of breast cancer are inconclusive. Formononetin, an isoflavone, induced apoptosis in human breast cancer cells by activating the Ras-p38 mitogen-activated protein kinase in ER-positive breast cancer cells (23). Any questions regarding your own health should be addressed to your own physician or other healthcare provider. While historically the RC plant has been taken in the form of tea and tinctures, today it’s often used to make extracts, such as the products … C'est pour cette raison que de […] Isoflavones are effective in treating several conditions such as hot flashes, cardivascular health and osteporosis. Avoid large amounts and use with caution. ALSO KNOWN AS: Cow clover, wild clover, purple clover, beebread, cow grass, meadow clover, purple clover. Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models View ORCID Profile Aurelie de Rus Jacquet , Abeje Ambaw , View ORCID Profile Mitali A Tambe , Michael Timmers , Sin Ying Ma , Qing-Li Wu , James E Simon , George P McCabe , Mary Ann Lila , Riyi Shi , View ORCID Profile Jean-Christophe Rochet Gynecol Endocrinol. Red clover leaf extract is to be used only by the patient for whom it is prescribed. Red clover is a perennial herb traditionally used to treat skin conditions such as eczema and psoriasis, whooping cough, and respiratory problems. In vivo prediction of CYP-mediated metabolic interaction potential of formononetin and biochanin A using in vitro human and rat CYP450 inhibition data. The British Journal of Nutrition discovered that red clover … Overuse of isoflavone supplements can increase the risk of hormone-sensitive cancer. It’s used to make an herbal supplement that may have some immune-boosting and positive hormonal effects, especially for postmenopausal women. The flower is also used for inflammatory conditions associated with arthritis and gout. Patients with hormone-sensitive cancers should avoid red clover because it has estrogenic activity, Red clover may increase effects of anticoagulants and antiplatelet drugs, Red clover causes toxic effects when used with methotrexate, © 2020 Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Integrative Medicine at Home Membership Program. Red clover (Trifolium pratense) is a medicinal herb containing flavonoids, coumarins, coumestans, and isoflavones. Red clover has long been used as a “blood purifier,” specifically for the potential treatment of cancer.  However, the red clover isoflavone biochanin A was shown to inhibit aromatase activity and expression, thereby conferring a protective effect. Studies of individual components of red clover show some cancer fighting action in vitro . Three: Blood flow seems to be enhanced by this herb since it can help prevent blood clots and thins the blood. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. They are found in legumes, such as soy and red clover (RC) and mimic the actions of estrogen through ER binding and activation of ER-dependent gene transcription . An isoflavone-enriched fraction showed neuroprotective activity in human cortical neurons as well, possibly due to antioxidant and estrogenic effects (4).