It’s sold over the counter and by prescription and tends to be slightly less irritating to the skin than tretinoin, making it worth considering if you have sensitive, easily-irritated facial skin.Â, Overall, both tretinoin and adapalene work well to remove and prevent acne. No systemic side effects were seen. Unlike tretinoin, which is exclusively a prescription medicine, the lower-strength 0.1 percent forms of topical adapalene are available as over-the-counter drugs in most pharmacies in the United States. In a review of tretinoin and adapalene, researchers found that tretinoin .05 percent gel “exhibits a greater anti-acne efficacy” than adapalene 0.1 percent gel. GPhC (1120908) This drug has risks. 176 5700 90) and Red Label Medical Ltd (Company Reg. Here's the important takeaway: Treclin is more expensive, but it is stronger than Differin and has antibiotic properties. Tretinoin can take several months before delivering noticeable results, so it’s important to understand it’s a process that takes time.Â, Topical tretinoin comes in several different strengths, ranging from .01 percent to .1 percent tretinoin. He is a registered pharmacist and the registered manager of our service with the CQC. Get the free app for Members. COVID-19: Treatments are being dispatched as usual. Get the free app for Doctors. Proactiv vs. Unblemish: What Works Best for Acne? What's the evidence? Furthermore, photodegradation of the molecule is less of a concern in comparison to tretinoin and tazarotene . There are other topical retinoids — tretinoin and tazarotene — used to treat acne, but adapalene is the only one available over the counter. Accordingly, numerous clinical trials have compared adapalene and tretinoin in the management of acne vulgaris and concluded that tretinoin 0.05% gel exhibits a greater anti-acne efficacy than adapalene 0.1% gel, but has higher skin irritation potential. However, it’s best to discuss your options with your healthcare provider to figure out what’s best for you. Tazorac medication. The retinoid family is an umbrella term that includes retinols and other vitamin A expressions, though the retinol term has come to refer to over-the-counter forms of … It's typically used to treat both inflammatory acne and comedonal breakouts. Tazorac moisturizer. Tretinoin cream vs retinol. Its common side effects include redness of the skin to an increase in sensitivity to sunlight. Adapalene is a more stable compound that does not break down. *Prescription products are subject to medical professional approval and require an online consultation with a physician who will determine if a prescription is appropriate. This approach can help you get the best results while limiting your risk of experiencing side effects from topical skin medication. see our policies and terms and conditions at the bottom of every page. Adapalene is a newer drug that’s slightly less effective at treating acne than tretinoin. In the study linked above, both medications showed an effective total decrease in acne lesions of 69 percent to 74 percent over the course of eight weeks. Tretinoin vs. Adapalene Scientists have performed several studies comparing the effectiveness of tretinoin to that of adapalene. Here's how they differ: Which is best all comes down to the severity and nature of your acne symptoms - we can assess your case and guide you towards the most suitable treatment. On the whole, studies comparing tretinoin and adapalene typically find that tretinoin is slightly more effective as an acne treatment. Because of this, it may not be recommended first if your goal is to reduce the visibility of wrinkles, creases or pigmented spots.Â. According to the articles I found on pubmed, tretinoin 0.025 and adapalene 0.1 have the same efficacy at the 12 week mark. This usually lasts for the first few weeks of use, and can be treated using moisturizer, sunscreen and other skincare products.Â, Overall, tretinoin has become something of an “industry standard” retinoid for good reason — it’s affordable, effective and safe. First, adapalene can inhibit keratinocyte differentiation, making it helpful for decreasing microcomedone formations, treating inflammation and exfoliating mature comedones. A 52-week study of adapalene 0.3 percent gel (the higher, prescription-only concentration of topical adapalene) found that only 21 percent of users experienced side effects from the treatment, of which the most common were dry skin, scaling and skin discomfort. Adapalene can also produce itching and redness — potential side effects that it shares with other topical retinoids. Simple said they all are just Vitamin A! The secret in Differin Gel (as compared with other retinoid formulations i.e. In general, irritation was mild, but was both more common and more severe in the tretinoin group vs. the adapalene group. $10/month. Get to clear skin with the Clear90 app. Skip to: full site navigation. Adapalene is synthesized in the laboratory using various chemicals including naphthoic acid. As members of the retinoid family, they're forms of Vitamin A, which has many roles: It's that last role of Vitamin A that retinoids focus on. 1998. Dr Don Grant is a GP with over 30 years experience and is the Clinical Advisor at The Independent Pharmacy.   I was wrong. 08676338). On paper, both drugs can look almost exactly the same, with similar benefits and potential side effects.Â. Our Tretinoin 101 guide, linked below, lists many of these studies, with plenty of data on how and why tretinoin works as an acne and anti-aging medication.Â, On the whole, tretinoin is a safe and effective drug. Please ensure you always read the information leaflets supplied with any medicinal products.For more information